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AssigneeT Cell Sciences, Inc.
InventorsPatrick C. Kung, Michael C. Brown, Stephen H. Ip
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Methods are provided for detecting and determining the amount in a sample of an antigenic determinant from an antigen receptor derived and released from a T cell or NK cell. Methods are also provided for detecting and determining the amount in a sample of an antigenic determinant from a complex of at least a portion of an antigen receptor derived from and released from a T cell or NK cell and a protein complex. These methods form the bases for methods of diagnosing and monitoring in a subject a disease characterized by the presence or an amount different from a normal subject of one of these antigenic determinants in a body fluid. A soluble antigen receptor or complex thereof derived from a T cell or a NK cell but free of such T cell or NK cell is also provided.
A method of monitoring in a subject a diseased condition caused by leukemia, lymphoma or viral infection characterized by the presence in a body fluid of the subject of an increase in quantity relative to healthy subjects of a molecule carrying an antigenic determinant of a T cell antigen receptor, which molecule is derived and spontaneously released from a T cell which comprises measuring the amount of the molecule in a series of body fluid samples taken over a period of time, identifying the presence or absence of an increase in quantity of the molecule in the body fluid samples over time and correlating the presence or absence of the increase with the diseased condition of the subject, in which the body fluid contains only such cell-free molecules carrying antigenic determinants of the T cell antigen receptor as are spontaneously released, and in which the T cell antigen receptor is a heterodimer consisting of monomers selected from the group consisting of the T cell antigen receptor alpha, beta, and gamma polypeptides.
A method for diagnosing in an animal a diseased state caused by leukemia, lymphoma or viral infection characterized by the presence in a body fluid of the animal of an increase in quantity relative to healthy animals of a molecule carrying an antigenic determinant of a T cell antigen receptor, which molecule is spontaneously released from a T cell which comprises detecting the increase in quantity of the molecule in the animal's body fluid and thereby diagnosing the diseased state, in which the body fluid contains only such cell-free molecules carrying antigenic determinants of the T cell antigen receptor as are spontaneously released, and in which the T cell antigen receptor is a heterodimer consisting of monomers selected from the group consisting of the T cell antigen receptor alpha, beta, and gamma polypeptides.
A method for diagnosing in a human subject a diseased state caused by leukemia, lymphoma or viral infection characterized by the presence in a body fluid of the subject of an increase in quantity relative to healthy humans of a molecule carrying an antigenic determinant of a T cell antigen receptor, which molecule is spontaneously released from a T cell which comprises detecting the increase in quantity of the molecule in the subject's body fluid and thereby diagnosing the diseased state, in which the body fluid contains only such cell-free molecules carrying antigenic determinants of the T cell antigen receptor as are spontaneously released, and in which the T cell antigen receptor is a heterodimer consisting of monomers selected from the group consisting of the T cell antigen receptor alpha, beta, and gamma polypeptides.
A method for diagnosing in a subject a diseased state caused by leukemia, lymphoma or viral infection characterized by the presence in a body fluid of the subject of an increase in quantity relative to healthy subjects of a molecule carrying an antigenic determinant of a T cell antigen receptor, which molecule (i) is derived and spontaneously released from a T cell, and (ii) is complexed to a T3 protein, which method comprises contacting a sample of the subject's body fluid with a known amount of a reagent which specifically binds to the antigenic determinant so as to form a reaction complex between the reagent and the molecule, determining the amount of reaction complex so formed, determining therefrom the amount of the molecule in the sample, comparing the amount of the molecule so determined with the amount present in a sample from a healthy subject, and thereby detecting the increase in quantity, in which the sample contains only such cell-free molecules carrying antigenic determinants of the T cell antigen receptor as are spontaneously released, and in which the T cell antigen receptor is a heterodimer consisting of monomers selected from the group consisting of the T cell antigen receptor alpha, beta, and gamma polypeptides.
A method for dianosing in a subject a diseased state caused by leukemia, lymphoma or viral infection characterized by the presence in a body fluid sample of the subject of an increase in quantity relative to healthy subjects of a molecule carrying an antigenic determinant of a T cell antigen receptor, which molecule (i) is spontaneously released from a T cell and (ii) is complexed to a T3 protein, which comprises detecting the increase in quantity of said molecule in a body fluid sample and thereby diagnosing the diseased state, which method comprises:
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