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US 4,841,067 AGranted
Novel amino acid derivatives
AssigneeKissei Pharmaceutical Co., Ltd.
InventorsKinji Iizuka, Tetsuhide Kamijo, Tetsuhiro Kubota, Kenji Akahane, Hideaki Umeyama, Yoshiaki Kiso
Life of this patent
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Abstract
Novel amino acid derivatives useful as a therapeutic agent are disclosed. These amino acid derivatives and the pharmaceutically acceptable salts thereof have a human renin inhibitory effect when administered orally and are useful for treatment of hypertension, especially renin-associated hypertension.
Claims21
An amino acid derivative represented by formula (I):
- ##STR20## wherein X represents a straight or branched chain alkoxycarbonyl group having 2 to 10 carbon atoms, or aralkoxycarbonyl group having 8 to 10 carbon atoms, a hydroxymethyl group, or ##STR21## wherein R.sup.1 represents a hydrogen atom an alkyl group having 1 to 6 carbon atoms, or an aralkyl group having 7 to 10 carbon atoms and R.sup.2 represents an alkyl group having 1 to 6 carbon atoms, or X represents --CH.sub.2 --Y--R wherein Y represents --O-- or --NH-- and R represents a straight or branched chain alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 10 carbon atoms, C.sup.(+) represents (+) form, His represents as L-histidyl group and C* represents a carbon atom in the L-configuration, m represents an integer of from 1 to 3, and n represents 0 or 1;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.