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AssigneeInstitut Pasteur
InventorsLuc Montagnier, Denise Guetard, Francoise Brun-Vezinet, Francois Clavel
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The invention relates to a new variety of retroviruses designated human immunodeficiency virus type II, HIV-II, samples of which have been deposited at CNCM as I-502 and I-532. It also concerns purified forms of the antigens which can be obtained from this virus, in particular from the gp 36 and gp 130-140 proteins. These various antigens are useful in medical diagnosis, in particular by being placed in contact with serum of the patient to be diagnosed. Lastly, the invention relates to immunizing compositions, in particular containing at least one of glycoproteins gp 36 and gp 130-140.
A human retrovirus, wherein the retrovirus is Human Immunodeficiency Virus Type 2 (HIV-2) in a biologically pure form.
Antigen of Human Immunodeficiency Virus Type 2 (HIV-2), wherein the antigen is protein antigen, glycoprotein antigen, or a mixture of protein and glycoprotein antigens and the antigen is free of human cells and of other LAV-II proteins and is capable of being immunologically recognized by serum of a patient afflicted with Lymphadenopathy Syndrome (LAS) or Acquired Immune Deficiency Syndrome (AIDS).
An extract of Human Immunodeficiency Virus Type 2 (HIV-2), wherein the extract comprises protein antigen, glycoprotein antigen, or a mixture of protein and glycoprotein antigens of the retrovirus and the antigen is free of human cells and of other LAV-II proteins and is capable of being immunologically recognized by serum of a patient afflicted with Lymphadenopathy Syndrome (LAS) or Acquired Immune Deficiency Syndrome (AIDS).
A lysate of Human Immunodeficiency Virus Type 2 (HIV-2), wherein the lysate comprises protein antigen, glycoprotein antigen, or a mixture of protein and glycoprotein antigens of the retrovirus and the antigen is free of human cells and of other LAV-II proteins and is capable of being immunologically recognized by serum of a patient afflicted with Lymphadenopathy Syndrome (LAS) or Acquired Immune Deficiency Syndrome (AIDS).
Isolate of a retrovirus, wherein the retrovirus has the identifying characteristics of the virus deposited under culture collection accession number C.N.C.M. No. I-502.
Isolate of a retrovirus, wherein the retrovirus has the identifying characteristics of the virus deposited under culture collection accession number C.N.C.M. No. I-532.
Dependencies are inferred from the claim text.