Topical metronidazole formulations and therapeutic uses thereof
AssigneeCuratek Pharmaceuticals, Inc.
InventorRobert J. Borgman
Life of this patent
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Abstract
Topical aqueous single-phase compositions containing metronidazole are disclosed. The compositions have improved specific activity and are substantially non-comedogenic, non-irritating and non-skin-drying. These aqueous topical compositions are particularly useful for treating rosacea and other acneform dermatological conditions, and certain forms of dermatitis.
Claims17
A dermatological preparation for topical application in the form of an aqueous gel composition comprising:
- a therapeutically effective amount of metronidazole as the sole active ingredient;
- a gelled, hydrophillic and water-dispersible polymer having free carboxylic groups which is a polyacrylic acid polymer having a molecular weight in the range of about 1,250,000 to about 4,000,000 daltons;
- and
- an aqueous solvent for said metronidazole.
A method for treatment of a human afflicted with a skin disorder which is a member of the group consisting of acne, rosacea, perioral dermatitis and seborrheic dermatitis, said method comprising topically applying to the afflicted skin region a therapeutically effective amount of a dermatological preparation in the form of an aqueous gel composition comprising:
- a therapeutically effective amount of metronidazole as the sole active ingredient;
- a gelled hydrophilic and water-dispersible polymer having free carboxylic groups which is a polyacrylic acid polymer having a molecular weight in the range of about 1,250,000 to about 4,000,000 daltons;
- and
- an aqueous solvent for said metronidazole.
Dependencies are inferred from the claim text.