Process for nucleophilic fluoroalkylation of aldehydes
AssigneeEthyl Corporation
InventorG. Patrick Stahly
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Abstract
Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula RCH(OH)CF.sub.2 SO.sub.2 Ar (I) wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.
Claims10
A process which comprises reacting under phase transfer condition an aryl difluoromethyl sulfone with an aldehyde co-reactive therewith so that there is produced a substituted alcohol of the formula
- RCH(OH)CF.sub.2 SO.sub.2 Ar
- wherein R is an aryl, cycloaliphatic, secondary or tertiary aliphatic or heterocyclic group, and Ar is an aryl group.
A process which comprises reacting in a liquid two-phase system of water and an organic solvent and in the presence of a strong inorganic base and a phase transfer catalyst and at a temperature in the range of about 20 to about 30.C, an aryl difluoromethyl sulfone with an aldehyde co-reactive therewith so that there is produced a substituted alcohol of the
- RCH(OH)CF.sub.2 SO.sub.2 Ar
- wherein R is an aryl, cycloaliphatic, secondary or tertiary aliphatic or heterocyclic group, and Ar is an aryl group.
Dependencies are inferred from the claim text.