Process for the preparation of cephalosporin derivatives
AssigneeKorea Advanced Institute of Science and Technology
InventorsMoon H. Chang, Bong J. Kim, Sung K. Kim, Woan J. Kim
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Abstract
The present invention relates to an improved process for producing cephalosporin derivatives of formula (I), the 3-position of which being substituted by acetoxymethyl or tetrazolylthiomethyl and the 7-acyl group of which being substituted by D-mandelic acid derivatives, which comprises simultaneously reacting the compound of formula (III) with the compound of formula (IV) in the presence of a compound of formula (II) and anamine in high yield, ##STR1## wherein, R.sup.1 is hydrogen or ##STR2## R.sup.2 is methyl, ethyl, propyl or phenyl, X is ##STR3##
Claims8
A process for preparing cephalosporin derivatives of formula (I) which comprises:
- reacting an effective amount of a carboxylic acid of formula (III) with an effective amount of a silylated intermediate of formula (IV) in the presence of an effective amount of a novel acylating agent of formula (II) in a single step process:
- ##STR8## wherein, R.sup.1 is hydrogen or ##STR9## R.sup.2 is methyl, ethyl, propyl or phenyl, X is ##STR10##
Dependencies are inferred from the claim text.