Use of charged nitroxides as NMR image enhancing agents for CSF
AssigneeM.R.I., Inc.
InventorGerald M. Rosen
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Abstract
Charged, stable, organic nitroxides, e.g., charged by a quaternary ammonium or a Bronsted acid group, are useful as NMR image enhancing agents for cerebrospinal fluid.
Claims16
A method of enhancing the image obtained by NMR scanning of a portion surrounding the spinal cord of the body of a vertebrate, which comprises injecting into the vertebrate's cerebrospinal fluid (CSF), a composition comprising a non-toxic injectable pharmacologically acceptable aqueous vehicle and an amount of a charged, stable organic nitroxide which is neurologically acceptable and non-toxic in the amount injected, effective to reduce the T. relaxation time of the CSF and scanning the spinal cord to obtain an enhanced NMR image.
Dependencies are inferred from the claim text.