Cephem compounds
AssigneeTakeda Chemical Industries, Ltd.
InventorsShoji Kishimoto, Kiminori Tomimatsu, Michiyuki Sendai
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Abstract
Cephem compounds of the formula: ##STR1## wherein Q stands for a nitrogen atom or CH, R.sup.1 stands for a hydrogen atom or an optionally substituted lower alkyl group, R.sup.2 stands for a hydrogen atom or a lower alkyl group, A stands for a sulfur atom or NH, and n denotes an integral number ranging from 2 to 4, or salts thereof, and processes for producing them. The compounds (I) or salts thereof show not only excellent antibacterial activities against a wide range of pathogenic bacteria from gram-positive to gram-negative ones, including a variety of strains isolated clinically but also hydrophilic properties, and therefore they are excellent antibiotic substances having desirable water-solubility when used as injections.
Claims8
A compound of the formula:
- ##STR31## wherein Q stands for a nitrogen atom or CH, R.sup.1 stands for a hydrogen atom or an optionally substituted lower alkyl group, A stands for a sulfur atom or NH, and n denotes an integral number ranging from 2 to 4, or a pharmaceutically acceptable salt thereof.
An antimicrobial composition which contains an effective antimicrobial amount of a compound of the formula ##STR33## wherein Q stands for a nitrogen atom or CH, R.sup.1 stands for a hydrogen atom or an optionally substituted lower alkyl group, A stands for a sulfur atom or NH, and n denotes an integral number ranging from 2 to 4, or a pharmaceutically acceptable salt thereof, together with a suitable carrier or carriers.
Dependencies are inferred from the claim text.