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US 4,831,031 AGranted
Aryl piperazinyl-(C.sub.2 or C.sub.4) alkylene heterocyclic compounds having neuroleptic activity
AssigneePfizer Inc.
InventorsJohn A. Lowe, III, Arthur A. Nagel
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Abstract
Arylpiperazinyl-ethyl(or butyl)-heterocyclic compounds and their pharmaceutically acceptable acid addition salts are neuroleptic agents. They are useful in the treatment of psychotic disorders.
Claims9
A compound of the formula ##STR4## or a pharmaceutically acceptable acid addition salt thereof, wherein Ar is benzoisothiazolyl or an oxide or dioxide thereof each optionally substituted by one fluoro, chloro, trifluoromethyl, methoxy, cyano, or nitro;
- n is 1 or 2;
- and
- X and Y together with the phenyl to which they are attached form benzothiazolyl;
- 2-aminobenzothiazolyl;
- benzoisothiazolyl;
- indazolyl;
- 2-hydroxyindazolyl;
- indolyl;
- oxindolyl optionally substituted by one to three of (C.sub.1 -C.sub.3)alkyl, or one of chloro, fluoro or phenyl, said phenyl optionally substituted by one chloro or fluoro;
- benzoxazolyl;
- 2-aminobenzoxazolyl;
- benzoxazolonyl;
- 2-aminobenzoxazolinyl;
- benzothiazolonyl;
- bezoimidazolonyl;
- or benzotriazolyl.
13 more elements
Dependencies are inferred from the claim text.