Metabolically acceptable polyisocyanate adhesives
AssigneeBioResearch Inc.
InventorsWilliam D. Fuller, Robert K. Blair, Murray Goodman
Life of this patent
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Abstract
Metabolically-acceptable, surgical adhesives are prepared from polyisocyanates having the structral formula: ##STR1## wherein R is a polyvalent aliphatic radical of about 1 to 10 carbon atoms or a polyvalent aromatic radical of 6 to about 24 carbon atoms; A is C, S or P; Z is O or S; Y is 1 when A is C or P, and 2 when A is S; n is 1 or 2; p is at least 1; q is 0 or 1, with the proviso that when A is carbon or sulfur, q is 0; r is 0 or 1, with the proviso that when A is carbon or sulfur, r is 0; X is a residue of an organic compound having active hydrogen-containing groups; and X' is a residue of an organic compound having at least 1 active hydrogen-containing group.
Claims47
A method of closing a wound in living tissue which comprises applying to the tissues to be bonded together a curable surgical adhesive comprised of
- A. a metabolically-acceptable polyisocyanate having the structural formula:
- ##STR48## wherein R is a polyvalent aliphatic radical of about 1 to 10 carbon atoms or a polyvalent aromatic radical of 6 to about 24 carbon atoms;
- A is carbon, sulfur or phosphorus;
- Z is oxygen or sulfur;
- y is 1 when A is carbon or phosphorus, and 2 when A is sulfur;
- n is 1 or 2;
- p is at least 1;
- q is 0 or 1, with the proviso that when A is carbon or sulfur, q is 0;
- r is 0 or 1, with the proviso that when A is carbon or sulfur, r is 0;
- and
- X is the residue of an organic compound having terminal active hydrogen-containing groups, and
- X' is a residue of an organic compound having at least 1 active hydrogen-containing group;
- or
- B. an excess of said polyisocyanate A above in admixture with an organic compound containing at least two active hydrogen atoms reactive with the polyisocyanate.
A composition comprising a polyisocyanate having the structural formula:
- ##STR63## wherein R is a polyvalent aliphatic radical of about 1 to 10 carbon atoms or a polyvalent aromatic radical of 6 to about 24 carbon atoms;
- A is carbon, sulfur or phosphorus:
- Z is oxygen or sulfur;
- y is 1 when A is carbon or phosphorus, and 2 when A is sulfur;
- n is 1 or 2;
- p is at least 1;
- q is 0 or 1, with the proviso that when A is carbon or sulfur, 1 is 0;
- r is 0 or 1, with the proviso that when A is carbon or sulfur, r is 0;
- X is the residue of a hydroxy-terminated polyester or polyether/polyester;
- and
- X' is the residue of an organic compound having at least 1 active hydrogen-containing group.
A curable polyisocyanate composition comprising a mixture of 5 to 95% by weight of a polyisocyanate I having the structure:
- ##STR69## and 5 to 95% of a polyisocyanate II having the structure:
- ##STR70## wherein R.sub.3 and R.sub.6 are aliphatic or aromatic radicals having 1 to 12 carbon atoms;
- R.sub.7 is a polyfunctional active hydrogen-containing aliphatic radical;
- f, g, h, m, p, and q are integers of at least 1;
- and Z is oxygen.
Dependencies are inferred from the claim text.