Non-crystalline minoxidil composition, its production and application
AssigneeLiposome Technology, Inc.
InventorsPaul S. Uster, Yolanda P. Quinn
Life of this patent
Estimating the term…
Abstract
An aqueous, noncrystalline minoxidil composition for topical use. The composition contains minoxidil complexed with an amphipathic compound having a pK less than about 5 and containing a single lipophilic chain moiety and a sulfate, sulfonate, phosphate and phosphonate polar moiety. The composition may be formulated in ointment form, in an aqueous vehicle, or dispersed in a fluorochlorocarbon solvent, for spray delivery from a self-propelled spray device.
Claims18
A non-crystalline minoxidil composition formed by complexing mnoxidil with the free acid form of an amphipathic compound having a pK less than about 5 and containing a single lipophilic chain moiety and a polar head group selected from the group consisting of a sulfate, sulfonate, phosphate and phosphonate group.
A non-crystalline minoxidil composition comprising minoxidil complexed with an ethoxylated sulfosuccininc acid hemiester having a pK less than about 5 and containing a single lipophilic chain moiety.
A method of applying minoxidil topically in a non-crystalline form which remains non-crystalline at least several hours after application to the skin, comprising complexing the minoxidil with the free acid form of an amphipathic compound having a pK less than about 5 and containing a single lipophilic chain moiety and a polar head group selected from the group consisting of a sulfate, sulfonate, phosphate and phosphonate group.
A method of producing a topical, non-crystalline minoxidil composition which remains non-crystalline at least several hours after application to skin, comprising complexing the minoxidil with the free acid form of an amphipathic compound having a pK less than about 5 and containing a single lipophilic chain moiety and a polar head group selected from the group consisting of a sulfate, sulfonate, phosphate and phosphonate group.
Dependencies are inferred from the claim text.