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AssigneeMallinckrodt Inc.
InventorsRichard T. Dean, Youlin Lin, Robert W. Weber, David H. White
Estimating the term…
The disclosure is directed to compounds of the formula: ##STR1## wherein n=0, 1, 2, 3 or 4, and R.sub.1 and R.sub.2 may be the sam e or different and are selected from the group consisting of hydrogen and lower alkyl and hydroxy lower alkyl groups containing between 1 and 6 carbon atoms. Complexes of iron(II), iron(III), manganese(II), manganese(III), gadolinium(III), chromium(III), cobalt(II), and nickel(II) and such compounds are useful for enhancing magnetic resonance images of body organs and tissues. Illustrative complexes include (N,N"-bis[N-(2,3-dihydroxypropyl) carbamoylmethyl]diethylenetriamine-N,N',N"-triaceto)-iron(III), (N,N"-bis[N-(2,3-dihydroxypropyl)carbamoylmethyl]diethylenetriamine-N,N',N "-triaceto)manganese(II), (N,N"-bis[N-(2,3-dihydroxypropyl) )carbamoylmethyl]diethylenetriamine-N,N',N"-triaceto)gadolinium(III) and (N,N'-bis[N-(2,3-dihydroxypropyl)-carbamoylmethyl]ethylenediamine-N,N'-dia ceto)manganese(II).
A compound of the formula:
A complex for use in enhancing magnetic resonance images of the body organs and tissues, said complex comprising one or more central metal ions selected from the group consisting of iron(II), iron(III), manganese(II), manganese(III), gadolinium(III), chromium(III), cobalt(II) and nickel(II) and a compound of the formula:
A method for enhancing magnetic resonance images of body organs and tissues which comprises administering to a mammal a complex of one or more central metal ions selected from the group consisting of iron(II), manganese(II), manganese(III), gadolinium(III), chromium(III), cobalt(II) and nickel(II) and a compound of the formula:
Dependencies are inferred from the claim text.