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US 4,824,993 AGranted
Cyclopentyl ethers and their preparation and pharmaceutical formulation
AssigneeGlaxo Group Limited
InventorsEric W. Collington, Harry Finch, Duncan B. Judd
Life of this patent
Estimating the term…
Abstract
Compounds are described of formula (I) ##STR1## in which n is 1 or 2; m is 2-5 and X is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; or m is 1-4 and X is --CH.dbd.C.dbd.CH--; R.sup.1 is --H, alkyl, phenalkyl, phenyl, substituted phenyl or naphthyl; Y substituted or unsubstituted 3-phenoxy-2-hydroxypropyl. These compounds inhibit gastric acid secretion and provide gastrointestinal cytoprotection, and may be formulated for use in the treatment of ulcers.
Claims20
Compounds of the general formula (I) ##STR11## wherein n is 1 or 2;
- m is 2-5 and X is cis or trans --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --;
- or m is 1-4 and X is --CH.dbd.C.dbd.CH--;
- R.sup.1 is
- (a) a hydrogen atom;
- C.sub.1-6 alkyl;
- C.sub.7-10 phenalkyl;
- or
- (b) phenyl [optionally substituted by C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkanoyl, methylthio, methylsulphinyl, methylsulphonyl, halogen, --CO.sub.2 R.sup.2 [where R.sup.2 is a hydrogen atom or C.sub.1-4 alkyl or phenyl], --NHCOR.sup.2 [where R.sup.2 is as defined above or is a phenyl group optionally substituted by hydroxyl, CH.sub.3 CONH-- or benzoylamino], --CONR.sup.3 R.sup.4 [where R.sup.3 and R.sup.4 may be the same or different and are each a hydrogen atom or C.sub.1-4 alkyl group], --NHCONH.sub.2, --CH.sub.2 CH(CONH.sub.2)NHCOCH.sub.3, or ##STR12## or (c) 2-naphthyl;
- Y is ##STR13## where R.sup.5, R.sup.6 and R.sup.7 are each a hydrogen atom or a methyl group and at least one is a hydrogen atom, and
- Ar is a phenyl group (optionally substituted by one or two C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphinyl, C.sub.1-4 alkylsulphonyl, halogen or trifluoromethyl groups)
- and the salts of compounds in which R.sup.2 is a hydrogen atom.
8 more elements
Dependencies are inferred from the claim text.