Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems

A process of producing antibody specific for 5'-terminal mono-, di- or tri-phosphorylated (2'-5') adenyl-adenosine oligonucleotides which comprises parenterally administering to a vertebrate living animal an immunogen consisting of an immunogenic substance coupled with a fully or partially 3'-ribose and 2'-terminal ribose acylated 5'-terminal mono- di- or tri-phosphorylated (2'-5') adenyl-adenosine oligonucleotide at time intervals suitable to induce immunization of said animal, gathering blood which contains the resulting specific antibody, and obtaining serum from said blood by clotting and optionally centrifugation or plasma from said blood by addition of anticoagulant and centrifugation.