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US 4,824,843 AGranted
Substituted amide inhibitors of cholesterol absorption
AssigneeWarner-Lambert Company
InventorsMilton L. Hoefle, Robert F. Meyer
Life of this patent
Estimating the term…
Abstract
Novel N-(substituted-phenyl)-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamides which are useful in preventing the intestinal absorption of cholesterol, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.
Claims25
A compound having the formula ##STR19## or a pharmaceutically acceptable acid addition salt thereof where R and R.sup.1 are each independently hydrogen, straight or branched alkyl of from one to nine carbon atoms, cycloalkyl of from three to seven carbon atoms or alkoxy of from one to six carbons;
- m is an integer from one to six;
- R.sup.2 and R.sup.3 are each independently hydrogen, straight or branched alkyl of from one to nine carbon atoms, or when taken together with the carbon atom to which they are attached, form a cycloalkyl ring of from three to seven carbon atoms;
- R.sup.4 and R.sup.5 are each independently hydrogen, straight or branched alkyl of from one to nine carbon atoms, cycloalkyl of from three to seven carbon atoms or alkoxy of from one to six carbons;
- X is --(CH.sub.2).sub.n --, --O--CH.sub.2 -- or ##STR20## wherein n is zero to four and R.sup.8 is hydrogen, straight or branched alkyl of from one to nine carbon atoms, or cycloalkyl of from three to seven carbon atoms;
- R.sup.6 and R.sup.7 taken together are --(CH.sub.2).sub.p --, --CH.dbd.CH--, ##STR21## wherein p is two or three, R.sup.9 and R.sup.10 are each independently hydrogen, straight or branched alkyl of from one to nine carbon atoms, cycloalkyl of from three to seven carbon atoms, or --CH.sub.2 OH and R.sup.8 is as described above.
2 more elements
Dependencies are inferred from the claim text.