Antibody conjugates
AssigneeImmunomedics, Inc.
InventorMarion F. Hawthorne
Life of this patent
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Abstract
An antibody or antibody fragment is modified by chemical linkage to a synthetic poly(amide/urea/thiourea) which contains a plurality of boron atoms or other functional groups, conferring upon the resultant conjugate desirable properties as a diagnostic and/or therapeutic agent. In a preferred embodiment, boron-containing groups are conjugated to the antibody/fragment such that the resultant conjugate contains 50-2000 boron atoms, with about 96% Boron-10 isotope content, to produce conjugates useful for neutron-activated radiotherapy of tumors or pathological lesions.
Claims17
A modified antibody or antibody fragment, consisting essentially of:
- (1) at least one hypervariable region which specifically binds a ligand such that the formation of the resultant immunological complex is of diagnostic or therapeutic utility;
- and
- (2) at least one defined, substantially homogeneous synthetic sequenced polymer whose constituent residues are linked by amide or urea or thiourea linkages or a combination thereof, and which incorporates residues containing a plurality of Boron-10 atoms;
- wherein said synthetic sequenced polymer is chemically bound to said antibody or antibody fragment at one or more sites which do not substantially interfere with the immunological specificity of said hypervariable region.
Dependencies are inferred from the claim text.