US 4,822,681 AGranted

Activated polymer solid bodies and processes for the production thereof

AssigneeVeb Leipziger Arzeimittelwerk

InventorsWerner Schossler, Hans-Friedrich Boeden, Martin Holtzhauer, Fritz Loth, Falk Hiepe, Dieter Bertram, Frank Mielke, Reinhard Muller, Dagmar Konjuchowa

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Abstract

A chemically modified and activated, hydroxyl-group-containing, natural or synthetic, polymeric solid body surface is disclosed, as well as a process for the activation of such solid body surfaces by means of organo-silanes and, if necessary, homo- or heterobifunctional reagent. The surfaces are used for the stable, simple and economical binding of proteins, nucleic acids, low-molecular ligands, cells, microorganisms and other biological materials, in biology, biotechnology and medicine.

Claims9

Dependent claims

Process for the activation of hydroxyl group-containing polymeric solid body carrier material surfaces, comprising reacting said hydroxyl groups to form chemical bonding with an organo-silane of the formula (I)

(XR'.sub.n').sub.n SiR.sub.4-n (I)
in which X carbonyl, carboxy, epoxy, isocyano, isothiocyano, nitroso, sulfhydryl or halocarbonyl, R' is alkyl, alkylphenyl or phenyl, R is alkoxy, phenoxy or halogen, n' is an integer from 0 to 20 and n is an integer from 1 to 3, or with two or more organo-silanes of formula (I), said two or more organo-silanes being provided together in mixture, or successively, said organo-silane being provided in a fluid phase.

Dependencies are inferred from the claim text.

Facts

Application: 07/009,195Filed 29 Jan 1987
Priority: DD 28658129 Jan 1986
Granted: 18 Apr 1989
Term ends: Not estimatedThe source records don’t support an estimate.

Classification37 codes

B01J 20/28023
Characterised by their form: fibres or filaments
B01J 20/261
Synthetic macromolecular compounds: obtained by reactions only involving carbon to carbon unsaturated bonds
B01J 20/262
Synthetic macromolecular compounds: obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by…
B01J 20/264
Synthetic macromolecular compounds: derived from different types of monomers, e.g. linear or branched copolymers, block copolymers, graft copolymers