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US 4,814,346 AGranted
Benzopyrans and use thereof in treating vascular diseases
AssigneeZyma SA
InventorsAlban I. Albert, Friedrich W. Zilliken
Life of this patent
Estimating the term…
Abstract
Isoflavans of the formula I ##STR1## wherein the groups OR, R', R" and ring B are as defined in the specification, exhibit valuable pharmacological properties, especially for the treatment of vascular diseases. They are prepared by methods known per se.
Claims13
A compound of the formula I ##STR15## wherein the group OR represents hydroxy;
- lower alkoxy which is unsubstituted or substituted by hydroxy, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, carboxy or lower alkoxycarbonyl;
- or lower alkanoyloxy;
- one of the radicals R' and R" represents hydroxy, lower alkoxy, lower alkanoyloxy or lower alkyl and the other one is hydrogen;
- or the groups OR and R' together form a bivalent methylenedioxy radical which is unsubstituted or substituted by lower alkyl and/or phenyl, and R" is hydrogen;
- or the groups OR and R" together form a bivalent methylenedioxy radical which is unsubstituted or substituted by lower alkyl and/or phenyl, and R' is hydrogen;
- and the ring B is unsubstituted or substituted by lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, phenyl, lower alkanoyloxy, halogen, amino, lower alkylamino, di-lower alkylamino, phenylamino, lower alkanoylamino, benzoylamino;
- lower alkylsulfonylamino, phenylsulfonylmino;
- lower alkanoyl, benzoyl, carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkylcarbamoyl, N,N-dilower alkylcarbamoyl, cyano, ureido, N-lower alkylureido, lower alkylsulfonyl;
- phenylsulfonyl;
- lower alkyl which is substituted by hydroxy, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, halogen, carboxy or lower alkoxycarbonyl;
- lower alkoxy which is substituted by hydroxy, lower alkoxy, amino, lower alkylamino, di-lower alkylamino, halogen, carboxy or lower alkoxycarbonyl;
- C.sub.3 -C.sub.7 -alkoxy;
- and/or bivalent methylenedioxy;
- or wherein the ring B is monosubstituted by hydroxy, methoxy or ethoxy, provided that R' is other than hydroxy, methoxy or ethoxy, if the group OR represents hydroxy, methoxy or ethoxy;
- or wherein the ring B is disubstituted by methoxy and lower alkoxy, provided in case of 2',4'-dimethoxy substitution that R' and R" are other than methoxy, if the group OR represents methoxy;
- with the proviso that the ring B must be substituted, if R' is hydroxy and the group OR represents hydroxy or methoxy;
- it being possible for all phenyl groups mentioned as such or in composed radicals to be unsubstituted or substituted by lower alkyl, lower alkoxy, halogen, hydroxy and/or nitro;
- or a salt thereof.
15 more elements
Dependencies are inferred from the claim text.