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US 4,812,446 AGranted
Pharmaceutical products providing enhanced analgesia
AssigneeThe Procter & Gamble Company
InventorLarry M. Brand
Life of this patent
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Abstract
An analgesic composition comprising capsaicin or a capsaicin analogue and an analgesic selected from the class of non-steroidal anti-inflammatory, antipyretic and analgesic drugs is disclosed. This combination has been found to exhibit unexpectedly enhanced analgesic activity in humans and lower animals without a corresponding increase in undesirable side effects.
Claims17
An analgesic composition comprising a safe and effective amount of:
- (a) a capsaicinoid analgesic compound of the general formula:
- ##STR8## wherein R.sub.1 is selected from the group consisting of OH and OCH.sub.3, X is selected from the group consisting of ##STR9## and R is a C.sub.16 -C.sub.21 cis-mono-unsaturated alkenyl;
- (b) a nonsteroidal analgesic selected from the group consisting of salicylates, salicylate-like analgesic-antipyretics, and the pharmaceutically acceptable salts thereof;
- and
- (c) a pharmaceutically-acceptable carrier;
- wherein the weight ratio of (a):(b) is from about 20:1 to about 1:20.
3 more elements
A method for providing analgesia in humans and lower animals which comprises administering concurrently to a human and lower animal in need of such treatment a safe and effective amount of:
- (a) a capsaicinoid analgesic compound of the general formula:
- ##STR10## wherein R.sub.1 is selected from the group consisting of OH and OCH.sub.3, X is selected from the group consisting of ##STR11## and R is a C.sub.16 -C.sub.21 cis-mono-unsaturated alkenyl;
- (b) a nonsteroidal analgesic selected from the group consisting of salicylates, salicylate-like analgesic-antipyretics, and the pharmaceutically acceptable salts thereof;
- and wherein the weight ratio of (a):(b) is from about 20:1 to about 1:20.
1 more element
Dependencies are inferred from the claim text.