Vitamin D compounds
AssigneeHoffmann-La Roche Inc.
InventorsEnrico G. Baggiolini, John J. Partridge, Shian-Jan Shiuey, Gary A. Truitt, Milan R. Uskokovic
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Abstract
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydrogen or fluorine are described. The compounds of formula I are useful as agents in the treatment of disease states characterized by metabolic calcium deficiencies. Examplary of such disease states are osteoporosis and renal osteodystrophy.
Claims15
A compound of the formula ##STR10## wherein R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydrogen or fluorine.
The compound in accordance with claim 2, 25-hydroxy-23-yne-26,26,26,27,27,27-hexafluorocholecalciferol.
The compound in accordance with claim 5, 25-hydroxy-23-yne-cholecalciferol.
A composition comprising a pharmaceutically effective amount of a compound of the formula ##STR11## wherein R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydrogen or fluorine, and
- a pharmaceutically acceptable carrier material.
A method for treating disease states characterized by metabolic calcium deficiencies which comprises administering an effective amount of a compound of the formula ##STR12## wherein R.sub.1 is hydrogen or hydroxy and R.sub.2 is hydrogen or fluorine.
Dependencies are inferred from the claim text.