Injectable implant composition having improved intrudability
AssigneeCollagen Corporation
InventorsDonald G. Wallace, Hertsel Reihanian, Bruce B. Pharriss, William G. Braun
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Abstract
Injectable aqueous suspensions of biomaterials, such as cross-linked collagen, that contain a biocompatible fluid lubricant, such as glycogen or maltose, are disclosed. The inclusion of the lubricant significantly improves the intrusion of the suspension into soft tissue.
Claims34
An injectable implant composition for soft tissue augmentation comprising an aqueous suspension of a particulate biomaterial containing a sufficient amount of a biocompatible fluid lubricant to significantly improve the intrudability of the composition, wherein said particles of biomaterial are fibrils or beads comprising natural or synthetic polymers, and wherein said fluid lubricant comprises a non-fibrillar high molecular weight charged polymer, a high molecular weight neutral polymer, or a low molecular weight neutral molecule.
A method of improving the intrudability of a particulate biomaterial into soft tissue comprising
- incorporating a sufficient amount of a biocompatible fluid lubricant in the suspension to enhance the intrudability of the suspension into the tissue, wherein said particles of biomaterial are fibrils or beads comprising natural or synthetic polymers, and wherein said fluid lubricant comprises a non-fibrillar high molecular weight charged polymer, a high molecular weight neutral polymer, or a low molecular weight neutral molecule.
Dependencies are inferred from the claim text.