1,4-dihydropyridines
AssigneeGlaxo Inc.
InventorsClaudio Semeraro, Dino Micheli, Daniele Pieraccioli, Giovanni Gaviraghi, Allan D. Borthwick
Life of this patent
Estimating the term…
Abstract
Compounds are described of the formula ##STR1## wherein R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group; R.sub.2 and R.sub.3 independently represent a C.sub.1-6 straight or branched alkyl chain which may be interrupted by an oxygen atom; R.sub.5 represents a straight or branched chain C.sub.1-13 alkyl group or a C.sub.5-8 cycloalkyl group which may be substituted by a C.sub.1-3 alkyl substitutent; The compounds represented by formula (I) reduce intracellular calcium ion cencentration by limiting transmembranal calcium ion influx and thus may be useful for the treatment of cardiovascular disorders such as hypertension.
Claims19
A compound of the formula I. ##STR10## wherein R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group;
- R.sub.2 and R.sub.3 independently represent a C.sub.1-6 straight or branched alkyl chain which may be interrupted by an oxygen atom;
- R.sub.5 represents a straight or branched chain C.sub.1-13 alkyl group or a C.sub.5-8 cycloalkyl group which cycloalkyl may be substituted by a C.sub.1-3 alkyl group.
4-(2-(3-(1 ,1-Dimethylethoxy)-3-oxo-1-propenyl)phenyl)-1,4-dihydro-2,6-dimethyl-3,5-py ridinedicarboxylic acid diethyl ester.
A compound selected from
- 4-(2-(3-(1,1-dimethylethoxy)-3-oxo-1-propenyl)phenyl)-1,4-dihydro-2,6-dimet hyl-3,5-pyridinedicarboxylic acid, 3-methyl ester, 5-(2-methylpropyl) ester;
- 4-(2-(3-(1,1-dimethylethoxy)-3-oxo-1-propenyl)phenyl)-1,4-dihydro-2,6-dimet hyl-3,5-pyridinedicarboxylic acid, dimethyl ester;
- 4-(2-(3-(1,1-dimethylethoxy)-3-oxo-1-propenyl)phenyl)-1,4-dihydro-2,6-dimet hyl-3,5-pyridinedicarboxylic acid, 3-methyl ester 5-ethyl ester.
A compound of the formula I ##STR11## wherein
- R.sub.1 and R.sub.4 independently represent a C.sub.1-4 alkyl group;
- R.sub.2 and R.sub.3 independently represent a C.sub.1-6 straight or branched alkyl chain which may be interrupted by an oxygen atom.
A compound of the formula ##STR12## wherein:
- R.sub.1 and R.sub.4 represent a methyl group;
- R.sub.2 and R.sub.3 independently represent a methyl, ethyl, isopropyl, isobutyl, propoxyethyl or methoxyethyl group;
- and
- R.sub.5 represents an isopropyl, tert butyl, 2,6-dimethyl-4-heptyl, octyl or cyclohexyl group or a cyclohexyl group substituted by a methyl group.
Dependencies are inferred from the claim text.