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US 4,801,539 AGranted
Fermentation method for producing hyaluronic acid
AssigneeShiseido Company, Ltd.
InventorsHidemichi Akasaka, Hisayuki Komasaki, Takayuki Arai
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Abstract
Streptolysin-free hyaluronic acid is produced by cultivating a microorganism belonging to a genus Steptococcus which is anhemolytic and is capable of producing hyaluronic acid (e.g., Streptococcus zooepidemicus FERM BP-784) in a culture medium.
Claims5
A method of preparing hyaluronic acid free from streptolysin comprising the steps of:
- a. obtaining an anhemolytic mutant of Streptococcus zooepidemicus microorganisms capable of producing hyaluronic acid;
- b. growing a culture of said anhemolytic mutant;
- c. recovering hyaluronic acid free from streptolysin from said culture of anhemolytic mutant.
Dependencies are inferred from the claim text.