Preparation of solid pharmaceutical forms
AssigneeBASF SE
InventorsHans-Helmut Goertz, Roger G. Klimesch, Klaus Laemmerhirt, Siegfried Lang, Axel Sanner, Reinhard Spengler
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Abstract
Process for the preparation of solid pharmaceutical forms by mixing one or more pharmaceutical active compounds with one or more fusible, pharmacologically tolerated binders and, if required, other conventional pharmaceutical auxiliaries, at from 50.degree. to 180.degree. C., and subjecting the mixture to injection molding or extrusion and shaping, wherein the fusible binder used is a NVP polymer which contains not less than 20% by weight of NVP as copolymerized units, and, where they are present, all of whose comonomers contain nitrogen and/or oxygen.
Claims9
A process for the preparation of a solid pharmaceutical form by mixing one or more pharmaceutical active compounds with one or more fusible pharmacologically tolerated binders and subjecting the mixture to injection molding or extrusion and shaping at from 50.degree.to 180.degree. C., wherein the fusible binder used is a solvent-free N-vinylpyrrolidone polymer which has a water content of not more than 3.5% by weight and contains not less than 20% by weight of N-vinylpyrrolid-2-one (as copolymerized units, all copolymerized comonomers contain) nitrogen and/or oxygen and, at least when the glass transition temperature of the mixture is above 120.degree. C., N-vinylpyrrolidone polymer is used which is obtained by polymerization in an organic solvent or using an organic peroxide as an initiator in aqueous solution, and the mixture does not contain any thermoplastics which are sparingly soluble in gastric juice.
Dependencies are inferred from the claim text.