Inhibitors of slow reacting substance of anaphylaxis

A compound having the structural formula III ##STR9## wherein T is a straight or branched chain alkyl having from 7-15 carbon atoms which may contain from 1-3 noncumulative double or triple bonds;

• U is --C.tbd.C--;
• V is a straight or branched chain alkylene having from 1 to 4 carbon atoms or is a direct bond;
• R.sup.2 and R.sup.3 may be the same or different and are independently selected from CH.sub.2 OR.sup.c {wherein R.sup.c is hydrogen, carboxylic acyl having from 1 to 6 carbon atoms, tetrahydropyran-2-yl or COCH.sub.2 CH.sub.2 CO.sub.2 H}, CHO, 2-tetrazolyl, COR.sup.d }wherein R.sup.d is hydroxy, alkoxy having from 1 to 6 carbon atoms, OCH.sub.2 OC(O)C(CH.sub.3).sub.3 or NHR.sup.e and wherein R.sup.e is hydrogen, alkyl having from 1 to 6 carbon atoms or CH.sub.2 CO.sub.2 H} or SO.sub.3 H, with the proviso that at least one of R.sup.2 and R.sup.3 is 2-tetrazolyl or carboxyl;
• Z and Z.sup.1 may be the same or different and are independently selected from straight or branched chain alkylene having from 1 to 12 carbon atoms which may contain from 1 to 3 noncumulative double or triple bonds;
• and
• R.sup.4 is hydrogen, hydroxyl, or is combined with Z to form a double bond as indicated by the dashed line "a" or a cyclopropyl ring as indicated by the dashed lines "b".