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US 4,797,477 AGranted
Process for preparing sialic acid derivatives
AssigneeMect Corporation
InventorsShoji Yoshimura, Yoichiro Tani, Youzi Matsuzaki, Masayoshi Ito, Yoshiyasu Shitori, Tomoya Ogawa
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Abstract
The present invention relates to a new process for preparing 3-O-(sodium(5-acetamide-3,5-dideoxy-alpha-D-glycero-D-galacto-2-noneuro pyranosyl)onate-1,2-di-O-tetradecyl-Sn-glycerol (3) consisting essentially of hydrolyzing a 3-O-(C.sub.1-5 alkyl(5-acetamide-4,7,8,9-tetra-O-acetyl-3,5-di-deoxy-alpha-D-glycero-D-ga lacto-2-noneuropyranosyl)onate)-1,2-di-O-tetradecyl-Sn-glycerol (1) in a single step, in an aqueous lower aliphatic alcohol solution of an alkali metal hydroxide.
Claims7
A process for preparing a compound represented by the formula:
- ##STR9## wherein Ac is acetyl and Alk is an alkali metal, consisting essentially of:
- hydrolyzing, in a single step, a compound of the formula:
- ##STR10## wherein Ac is as defined above and R is C.sub.1-5 alkyl, in an aqueous ROH solution of an alkali metal hydroxide.
Dependencies are inferred from the claim text.