Novel drug delivery system
AssigneeWarner-Lambert Company
InventorsShri C. Sharma, James J. Shaw, Robert K. Yang
Life of this patent
Estimating the term…
Abstract
A drug delivery system comprising a core material comprising a drug, and a hydrophobic matrix coating the core. The coating delays hydration of the drug and masks the taste of the drug. The coating comprises an emulsifier, an edible fatty acid or wax and a glyceride. The delivery system can be incorporated into various food products, pharmaceutical preparations and proprietary products.
Claims14
A dry particulate drug delivery system designed to be chewed or swallowed whole comprising:
- (A) cholestyramine in an amount of about 1% to about 75% and
- (B) a hydrophobic matrix comprising
- (i) about 0.5% to about 20% by weight of an emulsifier;
- and
- (ii) about 61% to about 95% by weight of an edible material having a melting point in the range of about 25.degree. C. to about 100.degree. C. selected from the group consisting of (a) fatty acids having an iodine value of about 1 to about 10, (b) natural waxes, (c) synthetic waxes and (d) mixtures thereof;
- and
- (iii) at least one glyceride, wherein the cholestyramine and hydrophobic matrix form an agglomerate, and
- (c) a coat effective to delay hydration until ingested comprising about 200% to baout 400% by weight of the agglomerate an edible material having a melting point in the range of about 25.degree. C. to about 100.degree. C. selected from the group consisting of (a) fatty acids having an iodine value of about 1 to about 10, (b) natural waxes, (c) synthetic waxes and (d) mixtures thereof;
- wherein the coat forms a protective barrier effective to prevent unpleasant taste perception for the cholestyramine agglomerate.
A dry particulate composite having a substantially hydrophobic exterior designed to be chewed or swallowed whole comprising
- (A) an agglomerated mixture of about 1% to about 75% of cholestyramine and a matrix wherein the matrix comprises:
- (i) about 0.5% to about 20% fat soluble lecithin;
- (ii) about 61% to about 90% of an edible material having a melting point in the range of about 25.degree. C. to about 100.degree. C. selected from the group consisting of (a) a fatty acid having an iodine value of about 1 to about 10;
- (b) natural waxes;
- (c) synthetic waxes;
- (d) and mixtures thereof;
- (iii) about 0.5% to about 30% of a glyceride;
- said composite having a melting point in the range of about 20.degree. C. to about 90.degree. C.
Dependencies are inferred from the claim text.