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US 4,795,741 AGranted
Compositions for therapeutic percutaneous embolization and the use thereof
AssigneeBiomatrix, Inc.
InventorsAdolf Leshchiner, Nancy E. Larsen, Endre A. Balazs, Sadek K. Hilal
Life of this patent
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Abstract
Percutaneous emboli are formed for therapeutic and/or corrective reasons by using a composition which includes crosslinked gells of hyaluronic acid (HA), hylan (HY) or mixed crosslinked gels of HA or HY with other materials, thrombin and cationic substances containing quaternary ammonium groups. Other optional materials include fillers and radio-opaque substances.
Claims29
A composition for effecting embolization in blood vessels which comprises a physical mixture of
- (a) a first component which is a cross-linked gel of hyaluronic acid, a cross-linked gel of hylan, or a mixed gel of hyaluronic acid or hylan co-cross-linked with at least one other hydrophilic polymer copolymerizable therewith;
- (b) a cationic organic substance containing quaternary ammonium groups;
- and
- (c) thrombin.
1 more element
Dependencies are inferred from the claim text.