Method of inhibiting HIV
AssigneesGene Labs, Inc., The Regents of the University of California
InventorsJeffrey D. Lifson, Michael S. McGrath, Hin-Wing Yeung, Kou M. Hwang
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Abstract
A method of inhibiting expression of HIV antigens in human blood cells infected with HIV. The infected cells are exposed to a plant protein or glycoprotein, such as trichosanthin or momorcharin, at a concentration sufficient to (a) produce a substantial reduction in the level of HIV antigen, and (b) effect a selective reduction in the number of HIV-infected cells, with respect to uninfected cells of the same type. The method is used to treat HIV infection in humans. In another aspect, the invention includes a method of screening drug agents effective in treating HIV infection in humans.
Claims13
A method of inhibiting expression of HIV antigens in human T lymphocytes and monocyte/macrophage cells infected with HIV, comprising
- exposing the infected cells to an anti-HIV protein selected from the group consisting of trichosanthin or momorcharin, at a protein concentration which is effective to produce a substantial reduction in viral antigen expression in HIV-infected cells.
A method of treating a human subject infected with HIV, comprising
- administering to the subject a dose of an anti-HIV protein selected from the group consisting of trichosanthin and momorcharin, at a concentration of anti-HIV protein sufficient to produce a substantial reduction in viral antigen expression in the patient's HIV-infected cells.
Dependencies are inferred from the claim text.