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US 4,795,627 AGranted
Tritium labelled N-mustard type compounds and a process for their production
AssigneeUniversity of Pittsburgh
InventorsAbraham Fisher, Israel Hanin, Donald J. Abraham
Life of this patent
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Abstract
The present invention describes novel tritium labelled nitrogen mustard type compounds, and their aziridinium type analog, and a process for the production of same. The compounds are of value in medical research and development and also as active ingredients of pharmaceutical compositions. The compounds can be used to develop analogs of human disease states and can also be used to evaluate the mechanism of neurotransmitter regulation and function, both in vitro and in vivo.
Claims15
A tritium labeled nitrogen mustard type compound of the structural formula:
- R.sub.1 R.sub.2 Q
- wherein Q is ##STR22## wherein R.sub.1 and R.sub.2 individually are from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, 2-acetoxyethyl, 2-halogenoethyl, 2-acetoxypropyl, hydroxyethyl, 2-hydroxypropyl, 1-methyl-2-acetoxyethyl, .gamma.-carboxypropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, 2-hydroxycyclopropyl, 2-acetoxycyclopropyl, 3-hydroxycyclopentyl, 4-hydroxycyclohexyl, phenyl, napthyl, pyrenyl, 1-pyrenebutyryl, mono-, di and trihydroxy-.beta.-phenyl-.alpha.-hydroxyethyl, o-methylbenzyl, o-bromobenzyl, .gamma.-substituted-n-butyric acid, and 2-substituted-1-(3,4-dihydroxyphenyl)ethanol, wherein the term "substituted", where used, designates the cite of attachment of R.sub.1 or R.sub.2 to Q wherein
- T is tritium
- X is halogen, and
- X'- is an anion.
2 more elements
Dependencies are inferred from the claim text.