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US 4,792,614 AGranted
Substituted furans as inhibitors of 3-hydroxy-3-methylglutaryl-coa reductase
AssigneeAmerican Home Products Corporation
InventorsWilliam F. Fobare, Donald P. Strike
Life of this patent
Estimating the term…
Abstract
Compounds of the formula: ##STR1## in which ##STR2## where M is hydrogen or alkyl; one of R.sup.2 and R.sup.3 is phenyl or substituted phenyl where the substituent is alkyl, alkoxy, halogen, trifluoromethyl, nitro, amino, cyano or carboxyl; and the other of R.sup.2 and R.sup.3 is hydrogen, alkyl, or a halogen; or a pharmaceutically acceptable salt thereof, are HMG--CoA reductase inhibitors useful in the treatment of atherosclerosis, hypercholesterolaemia, hyperlipaemia and similar disease states characterized by elevated cholesterol levels in the blood.
Claims10
A compound of the formula:
- ##STR9## in which ##STR10## where M is hydrogen or alkyl of 1 to 4 carbon atoms;
- one of R.sup.2 and R.sup.3 is phenyl or substituted phenyl containing 1 or 2 substituents which are, independently, alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms, halogen, trifluoromethyl, nitro, amino, cyano or carboxyl;
- and the other of R.sup.2 and R.sup.3 is hydrogen, alkyl of 1 to 8 carbon atoms;
- or a halogen;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.