Process for the preparation of 5-phenylsulfinyl-1H-2-(methoxycarbonylamino)-benzimidazole
AssigneeHoechst Aktiengesellschaft
InventorsStephen Lachhein, Hilmar Mildenberger, Hans-Joachim Ressel
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Abstract
A highly selective, inexpensive and quantitative process is described for the preparation of 5-phenylsulfinyl-1H-2-(methoxycarbonylamino)-benzimidazole (oxfendazole) through reaction of 5-phenylmercapto-1H-2-(methoxycarbonylamino)-benzimidazole with hydrogen peroxide in the presence of one or more aliphatic C.sub.1 -C.sub.6 -alcohols with addition of a strong, nonoxidizing mineral acid.
Claims7
A process for the preparation of 5-phenylsulfinyl-1H-2-(methoxycarbonylamino)-benzimidazole through reaction of 5-phenylmercapto-1H-2-(methoxycarbonylamino)benzimidazole with hydrogen peroxide, wherein the reaction is carried out in mineral acid in the presence of one or more aliphatic C.sub.1 -C.sub.6 -alcohols.
Dependencies are inferred from the claim text.