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AssigneeChisso Corporation
InventorsRyo Yoshizawa, Masatoshi Kawashima, Hitoshi Yano
Estimating the term…
5-Fluorouracil derivatives of this invention are represented by the general formula: ##STR1## wherein R indicates an alkylene group having 1-8 carbon atoms, A indicates an atomic group of --NH-- and --CO--, n is 0 or 1, and Y indicates an alkyl group having 1-10 carbon atoms, an aryl group, a heteroaryl group, a pyridinium ion having a halogen as a pair ion or an isocyanate group. These derivatives are useful as anticancer medicines and intermediates therefor. These derivatives are produced by six specified methods of this invention. A representative method is a process which comprises reacting 5-fluorouracil and an isocyanate represented by a general formula: Y--(A)n--R--NCO (VII) wherein R, A, n and Y are the same as those indicated in the formula (I).
A compound of the formula ##STR38## wherein R is a covalent bond, --CH.sub.2, --(CH.sub.2).sub.2 -- or --CH(COOC.sub.2 H.sub.5)CH.sub.2 --;
Dependencies are inferred from the claim text.
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No related US applications are recorded in the indexed filing history.
With other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring…:…
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
Term ended 2 Apr 2007 (estimated)
USPTO file history isn’t available for this patent, so only indexed dates are shown.
1. Fields of the Invention
This invention relates to new 5-fluorouracil derivatives useful for an anticancer medicine or intermediates thereof and processes for producing thereof.
2. Description of the Prior Art
The following examples illustrate this invention more specifically.
5-Fluoro-3,4-dihydro-2,4-dioxo-N-(2-thienyl)-1(2H-pyrimidinecarboxamide: ##STR12##
2-Thienyl isocyanate (3.09 g, 24.7 mmol) and 5-fluorouracil (3.21 g, 24.7 mmol) were added into a solvent of benzene (50 ml) and pyridine (20 ml), and stirred and refluxed at 80.degree. C. for 16 hours.