3- and 4-biphenyloxyaminoalkanes and related compounds as anti-inflammatory and analgetic agents
AssigneeSyntex (U.S.A.) Inc.
InventorsPeter H. Nelson, James P. Dunn, Stefan H. Unger, Thomas R. Thieme
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AssigneeSyntex (U.S.A.) Inc.
InventorsPeter H. Nelson, James P. Dunn, Stefan H. Unger, Thomas R. Thieme
Estimating the term…
Compounds useful for treating inflammation, swelling and associated pain, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: a is an integer of 0-3; b is an integer of 0-2; n is an integer of 3-12; each X and each Y are independently -halo, --R.sup.1, -alkoxy, or -phenyl; and B is selected from the group consisting of: --NR.sup.1 R.sup.2, --NR.sup.1 (CH.sub.2 CH.sub.2 OH), ##STR2## in which R.sup.1 and R.sup.2 are independently H, alkyl or cycloalkyl; R.sup.3 is H, alkyl or --CH.sub.2 CH.sub.2 OH; and m is an integer of 3-8. Novel compounds are those wherein n is at least 6 if both a and b are 0.
A method of preventing, reducing or inhibiting inflammation which method comprises administering to a mammal in need of such treatment a therapeutically effective amount of a compound of the formula:
A method of preventing, reducing or inhibiting localized inflammation and associated pain, which method comprises administering topically to a mammal in need of such treatment a compound of the formula:
Dependencies are inferred from the claim text.