Aryl pyrroles as useful antiallergy compounds
AssigneeRorer Pharmaceutical Corporation
InventorJoseph Auerbach
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Abstract
This invention relates to new lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties. The present new compounds are of the formula: ##STR1## and salts thereof; wherein, R is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower aralkyl, phenyl, naphthyl, or a nitrogen oxygen or sulfur heterocyclic; and Y.sub.1 and Y are independently hydrogen, lower alkyl, hydroxy, lower alkoxy, aryloxy, lower aralkoxy, aryl, lower aralkyl, carboxy, lower carbalkoxy, lower carbaralkoxy, carbaryloxy, formyl, or alkyl, alkenyl or alkynyl containing up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms; provided that when Y and Y.sub.1 are both hydrogen or when Y.sub.1 is hydrogen and Y is CHO, the R is other than hydrogen, unsubstituted phenyl, or lower alkyl.
Claims10
A thereapeutic composition for treating allergic condition in a mammal comprising:
- an inert pharmaceutically acceptable carrier;
- and a compound of the formula ##STR8## and its pharmaceutically acceptable salts, wherein Y is H, C.sub.1-6 alkanoyl, C.sub.1-6 alkyl or C.sub.1-6 alkenyl containing one double bond not attached directly to the pyrole, wherein the alkyl may be substituted with hydroxy or C.sub.1-6 alkoxy and the alkenyl may be substituted with carb-C.sub.1-6 -alkoxy.
A compound of the formula ##STR9## and its pharmaceutically acceptable salts, wherein Y is H, C.sub.1-6 alkanoyl, C.sub.1-6 alkyl or C.sub.2-6 alkenyl containing one double bond not attached directly to the pyrole, wherein the alkyl may be substituted with hydroxy or C.sub.1-6 alkoxy and the alkenyl may be substituted with carb-C.sub.1-6 -alkoxy.
A compound of the formula ##STR10## and its pharmaceutically acceptable salts, wherein Y is is CHO or C.sub.1-6 alkyl substituted with hydroxy.
The compound which is 1-(3-Phenoxyphenyl)pyrrole.
The compound which is 1-(3-Phenoxyphenyl)pyrrole-2-aldehyde.
The compound which is 1-(3-Phenoxyphenyl)pyrrole-3-aldehyde.
The compound which is 2-(1-Hydroxyhexyl)-1-(3-phenoxyphenyl)pyrrole.
The compound which is 3-(1-Hydroxyhexyl)-1-(3-phenoxyphenyl)pyrrole.
Dependencies are inferred from the claim text.