In-vial deposition of 7-(dimethylaminomethylene)amino-9.alpha.-methoxymitosane
AssigneeBristol-Myers Company
InventorsMurray A. Kaplan, Dolatrai M. Vyas, Nagaswara R. Palepu, Chih-Ming J. Chen
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Abstract
There is disclosed a process for the in-vial deposition of 7-(dimethylaminomethylene)amino-9a-methoxymitosane in sterile unit dosage form. A solution of this compound is introduced into a sterile vial in a solution of tertiary-butanol. The tertiary-butanol is then removed, e.g., by evaporation or lyophilization, and the vial is closed by appropriate means. The thus deposited material can contain up to 0.5 mole equivalent of tertiary-butanol as a hemi-solvate and is very stable to heat.
Claims18
A process for the in-vial deposition of 7-(dimethylaminomethylene)amino-9a-methoxymitosane in sterile unit dosage form which comprises introducing a solution of 7-(dimethylaminomethylene)amino-9a-methoxymitosane in tertiary-butanol into a sterile vial and thereafter removing the tertiary-butanol.
7-(Dimethylaminomethylene)amino-9a-methoxymitosane containing up to 0.5 mole equivalent of tertiary-butanol.
Dependencies are inferred from the claim text.