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US 4,792,560 AGranted
Quinoline hydroxamates and their use as modulators of arachidonic acid metabolic pathways
AssigneeRorer Pharmaceutical Corporation
InventorFu-chih Huang
Life of this patent
Estimating the term…
Abstract
This invention relates to new chemical compounds possessing valuable pharmaceutical activity, particularly as lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties.
Claims12
A compound of the formula:
- ##STR5## and pharmaceutically acceptable salts thereof wherein Ar is phenyl;
- Y is O or CR.sub.3 R.sub.4 ;
- X is O or CR.sub.3 R.sub.4 ;
- Z and Z.sub.1 are independently a chemical bond or an alkylene chain having up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms;
- Z.sub.2 is a chemical bond or an alkylene chain or a mono-substituted alkylene chain containing up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms and the substituents are hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, or C.sub.1 -C.sub.5 carbalkoxy;
- R is quinolyl;
- R.sub.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.5 cycloalkyl, phenyl or quinolyl;
- R.sub.2, R.sub.3 and R.sub.4 are each hydrogen or C.sub.1 -C.sub.5 alkyl;
- and n is an integer from 0-2, with the proviso that when n=0,
- R.sub.1 is quinolyl.
7 more elements
A compound of the formula:
- ##STR6## and pharmaceutically acceptable salts thereof;
- wherein R is quinolyl;
- R.sub.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, or phenyl;
- Z and Z.sub.1 are independently a chemical bond or an alkylene chain having up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms;
- Z.sub.2 is a chemical bond or an alkylene chain or a mono-substituted alkylene chain containing up to 6 carbon atoms in the principal chain and up to a total of 10 carbon atoms and the substituents are hydrogen, C.sub.1 -C.sub.5 alkyl, or carboxy;
- X is independently O or CR.sub.3 R.sub.4 ;
- R.sub.3 is independently hydrogen or C.sub.1 -C.sub.5 alkyl;
- n is 0, 1 or 2;
- and
- R.sub.5 is hydrogen.
7 more elements
A compound having the formula:
- ##STR7## and pharmaceutically acceptable salts thereof, wherein R is quinolyl;
- Z is a chemical bond or C.sub.1-3 alkylene;
- X is O or CR.sub.3 R.sub.4 ;
- Z.sub.2 is a chemical bond or C.sub.1-3 alkylene;
- R.sub.1 is C.sub.1-3 alkyl, phenyl, carboxy, or phenyl substituted with methoxy or chlorine;
- each R.sub.3 is independently hydrogen or C.sub.1-3 alkyl;
- and
- R.sub.4 is hydrogen or C.sub.1-3 alkyl.
5 more elements
Dependencies are inferred from the claim text.