2,4-diamino-5[4-amino (or dimethylamino)-3,5-dimethoxybenzyl]pyrimidine and antibacterial composition thereof
AssigneeHoffman-La Roche Inc.
InventorsIvan Kompis, G/e/ rald Rey-Bellet, Guido Zanetti
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Abstract
2,4-Diamino-5-benzylpyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2, A, Z and n are as hereinafter set forth, are described. The 2,4-diamino-5-benzylpyrimidines of the invention have useful antibacterial activity. More particularly, they inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulfonamides.
Claims11
An antibacterial composition comprising 2,4-diamino-5-(4-amino-3,5-dimethoxybenzyl)pyrimidine or a pharmaceutically acceptable acid addition salt thereof and a compatible pharmaceutical carrier.
An antibacterial composition comprising 2,4-diamino-5-[4-(dimethylamino)-3,5-dimethoxybenzyl]pyrimidine, or a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutically compatible carrier material.
Dependencies are inferred from the claim text.