Naphthalene anti-psoriatic agents
AssigneeSyntex (U.S.A.) Inc.
InventorsD. V. K. Murthy, Michael C. Venuti, John M. Young
Life of this patent
Estimating the term…
Loading patent…
AssigneeSyntex (U.S.A.) Inc.
InventorsD. V. K. Murthy, Michael C. Venuti, John M. Young
Estimating the term…
Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy or optionally substituted phenoxy, R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; at least one of X or Y is C(O)W and the other X or Y is different and is hydrogen, C(O)W or R.sup.4 wherein W is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl; and R.sup.4 is lower alkyl or optionally substituted phenyl-lower-alkyl.
A compound of the formula ##STR9## wherein:
Dependencies are inferred from the claim text.