Phospholipase A.sub.2 inhibitors

A method for treating inflammatory conditions which comprises administering to a subject in need thereof an anti-inflammatory effective amount of a compound having the formula ##STR5## wherein R.sup.1 is lower alkyl, lower alkoxycarbonyl lower alkyl, phenyl C.sub.1-3 alkoxycarbonyl, aralkoxycarbonyl lower alkyl or indol-2-yllower alkyl;

• R.sup.2 is hydrogen, lower alkyl or biphenylyl lower alkylcarbonyl;
• or
• R.sup.1 and R.sup.2 taken together form a pyrrolidine or piperidine ring;
• R.sup.3 is hydrogen or lower alkyl;
• R.sup.4 is alkyl of 10-20 carbons atoms, cycloalkyl of 10-20 carbon atoms or phenylalkyl of 10-16 carbon atoms;
• or
• R.sup.3 and R.sup.4 taken together are decahydroisoquinolin-2-yl, 3,5-dimethylpiperazin-1-yl or 3,3,5-trimethylhexadroazepin-1-yl, with the proviso that at least one of the pair R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 must be taken together to form a heterocyclic ring as hereinbefore defined;
• or a pharmaceutically acceptable salt thereof.

A pharmaceutical composition for treating inflammatory conditions comprising a compound having the formula ##STR6## wherein R.sup.1 is lower alkyl, lower alkoxycarbonyl lower alkyl, phenyl C.sub.1-3 alkoxycarbonyl, aralkoxycarbonyl lower alkyl or indol-2-yllower alkyl;

• R.sup.2 is hydrogen, lower alkyl or biphenylyl lower alkylcarbonyl;
• or
• R.sup.1 and R.sup.2 taken together form a pyrrolidine or piperidine ring;
• R.sup.3 is hydrogen or lower alkyl;
• R.sup.4 is alkyl of 10-20 carbon atoms, cycloalkyl of 10-20 carbon atoms or phenylalkyl of 10-16 carbon atoms;
• or
• R.sup.3 and R.sup.4 taken together are decahydroisoquinolin-2-yl, 3,5-dimethylpiperazin-1-yl or 3,3,5-trimethylhexahydroazepin-1-yl, with the proviso that at least one of the pair R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 must be taken together to form a heterocyclic ring as hereinbefore defined;
• and a pharmaceutically acceptable carrier.