Diene derivatives and vasodilators containing the same
AssigneeTerumo Kabushiki Kaisha
InventorsShin Hattori, Makoto Takai, Toshio Wakabayashi, Yasusi Suwabe, Syozo Miyaoka
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Abstract
Novel dienyl derivatives are disclosed. As examples of said diene derivative are mentioned 1-benzhydryl-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(3,4,5-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-(2,4-dimethoxyphenyl)-2,4-pentadienyl)pip erazine, 1-benzhydryl-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl) piperazine and the like. These dienyl derivatives are useful as vasodilators.
Claims23
A diene compound represented by the formula ##STR17## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and each represents a hydrogen atom or a C.sub.1 -C.sub.4 alkoxy group, and X represents a hydrogen atom or a halogen atom.
A pharmaceutical composition for treating cetebrovascular, coronary vascular or peripheral vascular disturbances said composition comprising a sufficient amount of a diene comound represented by the formula ##STR18## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and each represents a hydrogen atom or a C.sub.1 -C.sub.4 alkoxy group and X represents a hydrogen atom or a halogen atom, to treat cerebrovascular, coronary vascular or peripheral vascular disturbances and a pharamaceutically acceptable carrier.
A method for treating cerebrovascular, coronary vascular or peripheral vascular disturbances in a mammalian organism comprising administering to a mammalian organism in need of such treatment a sufficient amount of a diene compound represented by the formula ##STR19## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and each represents a hydrogen atom or a C.sub.1 -C.sub.4 alkoxy group, and X represents a hydrogen atom or a halogen atom.
Dependencies are inferred from the claim text.