13-aza-14-oxo-TXA.sub.2 analogues

A novel 13-aza-14-oxo-TXA.sub.2 analogue of general formula:

• ##STR129## wherein symbol A represents
• (i) a group of general formula:
• --CH.sub.2 CH.sub.2 --(CH.sub.2).sub.m --.
• (ii) a group of general formula:
• cis--CH.dbd.CH--(CH.sub.2).sub.m --,
• (iii) a group of general formula:
• --CH.sub.2 O--(CH.sub.2).sub.m --,
• (iv) a group of general formula:
• --S--(CH.sub.2).sub.m -- (wherein m represents an integer of from 1 to 6) or
• (v) a group of general formula:
• ##STR130## R.sup.1 represents a hydrogen atom or a straight or branched alkyl group of from 1 to 12 carbon atom(s);
• R.sup.2 represents a bond or a straight or branched alkylene or alkenylene group of from 1 to 10 carbon atom(s) unsubstituted or substituted by at least one of hydroxy group, amino group, halogen atom or phenylthio group;
• R.sup.3 represents
• (i) a phenyl, phenoxy or phenylthio group unsubstituted or substituted by at least one of straight or branched alkyl or alkoxy group of from 1 to 6 carbon atom(s), halogen atom or hydroxy group,
• (ii) a straight or branched alkyl, alkenyl or alkynyl group of from 1 to 6 carbon atom(s) unsubstituted or substituted by at least one of hydroxy group,
• (iii) a cycloalkyl, cycloalkyloxy or cycloalkylthio group of from 4 to 7 carbon atoms unsubstituted or substituted by at least one of straight or branched alkyl group of from 1 to 6 carbon atom(s), halogen atom or hydroxy group,
• (iv) a naphthyl, indolyl or indanyl group;
• and
• R.sup.4 represents a hydrogen atom or a methyl group;
• with proviso that R.sup.2 represents said alkylene or alkeneylene group of from 1 to 10 carbon atom(s) wherein the carbon atom neighboured with R.sup.3 in R.sup.2 has no substituents, where R.sup.3 represents a phenoxy, phenylthio, cycloalkyloxy or cycloalkylthio group unsubstituted or substituted;
• and cyclodextrin clathrates thereof and non-toxic salts thereof wherein R.sup.1 represents a hydrogen atom.