Trans-benzopyran-(4,3-b)-1,4-oxazine derivatives, intermediates and pharmaceutical use
AssigneeWarner-Lambert Company
InventorsHorace A. DeWald, Lawrence D. Wise
Life of this patent
Estimating the term…
Abstract
trans-Benzopyran-4,3b-1,4-oxazines are described as well as methods of preparation. The compounds are presynaptic dopamine agonists and may be used in pharmaceutical composition form for treating psychoses, e.g., schizophrenia.
Claims15
A compound of the formula ##STR10## wherein R is hydrogen, lower alkyl, phenyl lower alkyl or phenyl lower alkyl in which phenyl is substituted by lower alkyl, lower alkoxy, hydroxy, halogen, or trifluoromethyl;
- X is hydroxy, lower alkyl, lower alkoxy, halogen, or benzyloxy, or a pharmaceutically acceptable acid addition salt thereof.
A compound of the formula ##STR11## wherein R is hydrogen, lower alkyl, phenyl lower alkyl or phenyl lower alkyl in which phenyl is substituted by lower alkyl, lower alkoxy, hydroxy, halogen, or trifluoromethyl, and X is hydroxy, lower alkyl, lower alkoxy, halogen, or benzyloxy.
Dependencies are inferred from the claim text.