Rigolettone antitumor complex
AssigneeBristol-Myers Company
InventorsDonald E. Nettleton, Jr., Stanley W. Bray, James A. Bush, William T. Bradner
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Abstract
A novel complex designated herein as rigolettone complex is produced by fermentation of Streptomyces aburaviensis strain C-38,242 (ATCC 39290). The complex and its purified bioactive components, jildamycin and mantuamycin, exhibit antitumor activity in mouse tumor systems.
Claims6
The compound jildamycin having the formula ##STR2## wherein R is --CH.sub.3.
The compound mantuamycin having the formula ##STR3## wherein R is --CH.sub.2 CH.sub.3.
The process for the production of the compound jildamycin which comprises cultivating a jildamycin-producing strain of Streptomyces aburaviensis in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen under submerged aerobic conditions until a substantial amount of jildamycin is produced by said organism in said culture medium and then recovering said jildamycin from the culture medium substantially free of coproduced substances.
The process for the production of the compound mantuamycin which comprises cultivating a mantuamycin-producing strain of Streptomyces aburaviensis in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen under submerged aerobic conditions until a substantial amount of mantuamycin is produced by said organism in said culture medium and then recovering said mantuamycin from the culture medium substantially free of co-produced substances.
Dependencies are inferred from the claim text.