Generic zero order controlled drug delivery system
AssigneePfizer Inc.
InventorGautam R. Ranade
Life of this patent
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Abstract
A device for zero order releasing of biologically active substances into a fluid medium comprising a cylindrical tablet or bolus covered with an impermeable wall or coating from which strips of said wall or coating have been removed.
Claims32
A device for the controlled release of one or more active substances into a fluid medium at a substantially constant rate which comprises said substance homogeneously dispersed, with or without one or more inert excipients, and contained substantially in the shape of a cylindrical tablet or bolus by means of an all-covering essentially impermeable wall or coating except for one or more strips of removed wall or coating from the side of said device.
A bolus for oral administration into the reticulum or rumen of a ruminant mammal, said bolus being retained in said rumen or reticulum and releasing one or more active substances into the environment of said rumen or reticulum at a substantially constant rate over a prolonged period of time, which comprises said active agent or substances homogeneously dispersed in a matrix and contained by means of an all-covering essentially impermeable wall or coating except for one or more strips of removed wall or coating from the side of said bolus.
A tablet for oral administration to a mammal which releases a pharmaceutically active substance into the fluid of the gastrointestinal tract of said mammal at a substantially constant rate over an appreciable time interval which comprises said substance homogeneously dispersed, with or without one or more pharmaceutically-acceptable excipients and contained by means of an all-covering impermeable wall or coating except for one or more strips of removed wall or coating from the side of said tablet.
Dependencies are inferred from the claim text.