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AssigneeBoard of Regents, The University of Texas System
InventorsJonathan W. Uhr, Ellen S. Vitetta
Estimating the term…
Highly specific antibodies directed against immunoglobulin determinants coupled to one or more toxin molecules provide antibody-toxin conjugates which are useful in selectively inhibiting the growth of target immunoglobulin generating cells. The antibody-toxin conjugate consists of an antibody specific for a selected immunoglobulin determinant including isotypic, allotypic or idiotypic variable determinants, coupled to one or more toxin molecules. Anti-idiotype toxin conjugates are provided which have specificity which distinguishes B cell tumor cells from normal B cells. Also disclosed is an antibody-toxin conjugate consisting of anti-IgD A chain. The antibody-toxin conjugate is used as a cell or tumor specific cytotoxic agent directed selectively against those cells expressing the corresponding immunoglobulin to which the antibody portion has specificity.
A method of therapeutic intervention in the treatment of B cell tumors in a mammalian host exhibiting a B cell tumor, the method comprising:
A tumor suppressive antibody-toxin conjugate selectively reactive against B cell lymphocytes bearing the immunoglobulin IgD, which consists of:
Dependencies are inferred from the claim text.