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US 4,792,329 AGranted
Multi-compartment syringe
AssigneeDuphar International Research B.V.
InventorJohan C. Schreuder
Life of this patent
Estimating the term…
Abstract
The invention relates to a multi-compartment syringe comprising an ampoule having a plunger, a sealing stopper and at least one separating stopper between the plunger and the sealing stopper, and a needle holder consisting of a collar, a neck for an injection needle, a shaft between the collar and the neck and a by-pass means in the inner wall of the shaft, the space in the shaft of the needle holder being at least slightly longer than the sealing stopper, the ampoule wall comprising a liquid by-pass means through which the liquid behind the separating stopper or stoppers can reach the substance in front of the separating stopper or front separating stopper and can mix with same or can dissolve it, the ampoule, before use of the syringe, comprising an empty space in front of the sealing stopper.
Claims14
A multi-compartment syringe for separate storage of at least two different substances to be prevented from being in contact with each other except for a period of time immediately prior to use, one of said substances being disposed at a foremost position in said syringe, said syringe comprising:
- a hollow substantially cylindrical ampoule which is open at both ends,
- a plunger to which a plunger rod is connected and which is movable in the ampoule from an initial position at one end of the ampoule toward another end thereof and seals said ampoule,
- a sealing stopper having dimensions such that the sealing stopper can be provided in a sealing manner in said ampoule and so as to be movable in the ampoule in order to be able to separate the substance disposed at said foremost position in the ampoule from a front end of the ampoule,
- at least one rotationally symmetrical separating stopper means provided in the ampoule between said plunger and said sealing stopper and being movable therein, the circumference of said separating stopper means before use of the syringe adjoining the inner wall of the ampoule in a sealing manner and keeping the different substances present in the ampoule separated from each other, and
- a needle holder comprising:
- (a) a collar connected to the front end of the ampoule in a sealing manner,
- (b) a neck having an injection needle sealably attached thereto and covered by a needle guard to keep the needle in a sterile condition, said needle guard comprising a bacteria filter,
- (c) a hollow, substantially cylindrical shaft disposed between said collar and said neck, the shaft being proportioned so that the space bounded by the inner wall of the shaft and the rear face of the neck has one of (i) substantially the same circumference as and (ii) a slightly larger circumference than the inner wall of the ampoule and is at least longer than the sealing stopper, and
- (d) a needle holder by-pass means in the inner wall of the shaft through which injection liquid behind the sealing stopper can reach the injection needle when, during use of the syringe, the sealing stopper is moved forward into the shaft of the needle holder, said syringe being characterized in that an ampoule by-pass means is formed in the wall of the ampoule, which by-pass means has a length at least as great as that of the separating stopper means, and through which by-pass means, during use of the syringe, liquid behind the separating stopper means can reach the substance in front of the separating stopper means and can mix with said substance or can dissolve it, but which by-pass means, before use of the syringe, is sealed from the liquid present behind said separating stopper means by means of the separating stopper means, and the ampoule, before use of the syringe, comprises an empty space which is not filled with substance and which is bounded on the rear and lateral sides by the front face of the sealing stopper and the inner wall of the ampoule, and which on its front is in open communication with the space in the shaft of the needle holder, said empty space in the ampoule being at least as long as the distance from the front face of the plunger when said plunger is in its initial position at said one end of the ampoule to the rear end of said ampoule by-pass means.
6 more elements
A syringe, comprising:
- a hollow, substantially cylindrical ampoule which is open at both ends,
- a plunger which is movable in the ampoule and seals said ampoule and to which a plunger rod is connectable,
- a substantially rotationally symmetrical sealing stopper having dimensions such that the sealing stopper can be provided in a sealing manner in said ampoule and so as to be movable in the ampoule, and
- a needle holder comprising:
- (a) a collar connected to the front end of the ampoule in a sealing manner,
- (b) a neck for sealingly attaching an injection needle, covered by a needle guard to keep the needle in a sterile condition,
- (c) a hollow, substantially cylindrical shaft disposed between the collar and the neck, the shaft being proportioned so that the space bounded by the inner wall of the shaft and the rear face of the neck has one of (i) substantially the same circumference as and (ii) a slightly larger circumference than the inner wall of the ampoule and is at least longer than the sealing stopper, and
- (d) a needle holder by-pass means in the inner wall of the shaft through which injection liquid behind the sealing stopper can reach the injection needle when, upon using the syringe, the sealing stopper is moved forward into the shaft of the needle holder, said syringe being characterized in that the rear face of the sealing stopper comprises a plurality of recesses which are provided in the circumferential edge of the sealing stopper, and in that a circumferential groove is recessed in the backmost portion of the shaft of the needle holder adjoining the ampoule.
5 more elements
A syringe, comprising:
- a hollow, substantially cylindrical ampoule which is open at both ends,
- a plunger which is movable in the ampoule and seals said ampoule and to which a plunger rod is connectable,
- a substantially rotationally symmetrical sealing stopper having dimensions such that the sealing stopper can be provided in a sealing manner in said ampoule and so as to be movable in the ampoule, and
- a needle holder comprising:
- (a) a collar connected to the front end of the ampoule in a sealing manner,
- (b) a neck for sealingly attaching an injection needle, covered by a needle guard to keep the needle in a sterile condition,
- (c) a hollow, substantially cylindrical shaft disposed between the collar and the neck, the shaft being proportioned so that the space bounded by the inner wall of the shaft and the rear face of the neck has one of (i) substantially the same circumference as and (ii) a slightly larger circumference than the inner wall of the ampoule and is at least longer than the sealing stopper, and
- (d) a needle holder by-pass means in the inner wall of the shaft through which injection liquid behind the sealing stopper can reach the injection needle when, upon using the syringe, the sealing stopper is moved forward into the shaft of the needle holder,
- said syringe being characterized in that the rear face of the sealing stopper comprises a plurality of spacing supports which are provided on the circumferential edge of the sealing stopper.
6 more elements
A syringe, comprising:
- a hollow, substantially cylindrical ampoule which is open at both ends,
- a plunger which is movable in the ampoule and seals said ampoule and to which a plunger rod is connectable,
- a substantially rotationally symmetrical sealing stopper having dimensions such that the sealing stopper can be provided in a sealing manner in said ampoule and so as to be movable in the ampoule,
- at least one separating stopper disposed in the ampoule in a sealing manner so as to keep at least two different substances separated from each other prior to use of the syringe, and
- a needle holder comprising:
- (a) a collar connected to the front end of the ampoule in a sealing manner,
- (b) a neck for sealingly attaching an injection needle, covered by a needle guard to keep the needle in a sterile condition,
- (c) a hollow, substantially cylindrical shaft disposed between the collar and the neck, the shaft being proportioned so that the space bounded by the inner wall of the shaft and the rear face of the neck has one of (i) substantially the same circumference as and (ii) a slightly larger circumference than the inner wall of the ampoule and is at least longer than the sealing stopper, and
- (d) a needle holder by-pass means in the inner wall of the shaft through which injection liquid behind the sealing stopper can reach the injection needle when, upon using the syringe, the sealing stopper is moved forward into the shaft of the needle holder,
- said syringe being characterized in that the rear face of the sealing stopper comprises a plurality of recesses which are provided in the circumferential edge of the sealing stopper, and in that a circumferential groove is recessed in the backmost portion of the shaft of the needle holder adjoining the ampoule.
7 more elements
A syringe, comprising:
- a hollow, substantially cylindrical ampoule which is open at both ends,
- a plunger which is movable in the ampoule and seals said ampoule and to which a plunger rod is connectable,
- a substantially rotationally symmetrical sealing stopper having dimensions such that the sealing stopper can be provided in a sealing manner in said ampoule and so as to be movable in the ampoule,
- at least one separating stopper disposed in the ampoule in a sealing manner so as to keep at least two different substances separated from each other prior to use of the syringe, and
- a needle holder comprising:
- (a) a collar connected to the front end of the ampoule in a sealing manner,
- (b) a neck for sealingly attaching an injection needle, covered by a needle guard to keep the needle in a sterile condition,
- (c) a hollow, substantially cylindrical shaft disposed between the collar and the neck, the shaft being proportioned so that the space bounded by the inner wall of the shaft and the rear face of the neck has one of (i) substantially the same circumference as and (ii) a slightly larger circumference than the inner wall of the ampoule and is at least longer than the sealing stopper, and
- (d) a needle holder by-pass means in the inner wall of the shaft through which injection liquid behind the sealing stopper can reach the injection needle when, upon using the syringe, the sealing stopper is moved forward into the shaft of the needle holder,
- said syringe being characterized in that the rear face of the sealing stopper comprises a plurality of spacing supports which are provided on the circumferential edge of the sealing stopper.
7 more elements
Dependencies are inferred from the claim text.