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US 4,791,207 AGranted
Enantioselective process for producing 1-betamethylcarbapenem antibiotic intermediates
AssigneeMerck & Co., Inc.
InventorsThomas N. Salzmann, Lelia M. Fuentes, Ichiro Shinkai
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Abstract
A process is described for the stereochemically controlled synthesis of intermediates useful in producing 1-betamethylcarbapenem antibiotics.
Claims6
A compound of the formula:
- ##STR90## wherein X.sup.1 and X.sup.2 are independently O or S, R.sup.1 is C.sub.1 -C.sub.4 lower alkyl or alkoxyl, R.sup.4, R.sup.5 and R.sup.6 are independently selected from H, C.sub.1 -C.sub.4 alkyl, C.sub.7 -C.sub.10 aralkyl, C.sub.6 -C.sub.10 aryl, C.sub.7 -C.sub.10 alkaryl, which can be substituted with --OH, --OR.sup.10, --SH, SR.sup.10, where R.sup.10 is C.sub.1 -C.sub.4 alkyl, with the proviso that R.sup.4 and R.sup.5 are not identical.
Dependencies are inferred from the claim text.