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US 4,791,192 AGranted
Chemically modified protein with polyethyleneglycol
AssigneeTakeda Chemical Industries, Ltd.
InventorsYasushi Nakagawa, Takashi Ito
Life of this patent
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Abstract
The chemically modified protein of the present invention has a strong islet-activating activity and is lower in various side effects than non-modified IAP, so that it may be employed as a prevention and therapeutic drug for diabetes.
Claims16
A chemically modified protein with insulin secreting activity which comprises an islet-activating protein produced by bacteria belonging to the genus Bordetella and polyethylene glycol moiety of the formula
- --O--CH.sub.2 CH.sub.2 O).sub.l R
- where R is a protective group for hydroxyl and l is an integer of about 7 to 700, the polyethylene glycol moiety being bound with a primary amino group of the islet-activating protein.
Dependencies are inferred from the claim text.