Pharmacologically active ketones and use
AssigneeBurroughs Wellcome Co.
InventorsJohn F. Batchelor, Richard M. Hyde, David J. Livingstone
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Abstract
Use of compounds of formula (I) ##STR1## to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient. In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia; in vitro the compounds are of use in the storage of mammalian, including human, red blood cells to maintain their oxygen-delivery capacity and prolong their useful storage life. Also provided is a sterile, sealed vessel containing an anticoagulant, a non-toxic amount of a compound of formula (I) and optionally mammalian, in particular human, red blood cells.
Claims12
A method for increasing the delivery of oxygen to the tissues of a mammal in need of an increased amount of oxygen to its tissues comprising administering to said mammal in need thereof a non-toxic, oxygen delivery increasing amount of a compound of formula (I) ##STR3## wherein one of Z.sup.2 and Z.sup.3 is selected from the group consisting of hydroxyl and a group --O(C.sub.n H.sub.2n)X
- where
- X is selected from the group consisting of hydrogen and hydroxyl and
- n is an integer from 1 to 3
- provided that when X is hydroxyl then n is always greater than 1 and no single carbon atom in the radical --(C.sub.n H.sub.2n)-- is attached to both oxygen atoms and
- the other of Z.sup.2 and Z.sup.3 is hydrogen,
- or a pharmacologically acceptable salt thereof.
A method for the relief of tissue hypoxia in a mammal suffering from tissue hypoxia comprising administering to said mammal suffering from tissue hypoxia and in need thereof a non-toxic, tissue hypoxia relieving amount of a compound of formula (I) ##STR4## wherein one of Z.sup.2 and Z.sup.3 is selected from the group consisting of hydroxyl and a group --O(C.sub.n H.sub.2n)X
- where
- X is selected from the group consisting of hydrogen and hydroxyl and
- n is an integer from 1 to 3,
- provided that when X is hydroxyl then n is always greater than 1 and no single carbon atom in the radical --(C.sub.n H.sub.2n)-- is attached to both oxygen atoms and
- the other of Z.sup.2 and Z.sup.3 is hydrogen,
- or a pharmacologically acceptable salt thereof.
Dependencies are inferred from the claim text.